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Implication of Intestinal Barrier Dysfunction in Gut Dysbiosis and Diseases

The most significant symptoms related to vitamin B 12 deficiency are fatigue, memory impairment, skin pallor, glossarist, and severe hematological and neurological disorders [10–14]

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These extracellular adhesion points are the most targetable TJ component for modulation of the paracellular barrier ( Within the intestinal tract, various claudin isoforms are expressed in a segment-specific manner, contributing to the unique barrier properties of selected regions